Beta Cell Toxicity

Discuss the relationship among B-cell toxicity and diabetes type II; what is the role of activated atomic rate 8 species? Type II diabetes, non-insulin dependent, is a progressive disease characterized by insulin resistance and pancreatic B-cell recreate apoptosis which result in hyperglycaemia (Mahan, Escott-Stump, & Ramond, 2012). The resulting hyperglycemia induces, and is exacerbated by irreversible B-cell toxicity, which furthers the negative effects of insulin sensitivity and insulin secernment (Mahan et al., 2012). This is supported by Robertoson, Takahashi, Tanaka, and Tran (2003), whose look for indicated that hyperglycemia associated with type 2 diabetes is a secondary relieve oneself of beta-cell toxicity. B-cell toxicity develops over elongated exposure to high glucose denseness and results in damage to cellular components of insulin production that effect insulin assiduousness and secretion (Robertson et al., 2003). Robertson et al. found that the gismo of B-cell glucose toxicity involves pancreas duodenum homeobox-1 (PDX-1), a springy regulator of insulin promoter activity. Roberson let out in vivo, that Zucker diabetic juicy (ZDF) rats lost islet B-cell deoxyribonucleic sour binding activity of PDX-1 and insulin cistron expression as they more and more developed more tough hyperglycemia.

In the same study, Roberson in like manner sight that PDX-1 and insulin were preserved, and glycemic control was improved when the ZDF rats were inured with either an antioxidant or get down blood glucose levels. These findings suggest that B-cell toxicity is also a government issue of aerophilic stress. Chronic oxidative stress end-to-end the remains is often associated with hyperglycemia because the overweening glucose concentrations form reactive atomic number 8 species (ROS), and increased ROS is common in the pathogenesis of diabetes (Drews, Krippeit-Drews, & Dufer, 2010). B-cells atomic number 18 especially at risk as a grade for ROS. They have especially low antioxidant defense mental object because they...If you urgency to get a full essay, order it on our website: Ordercustompaper.com

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